Nicole C. Kleinstreuer: search on Z-Library

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1

Adverse outcome pathways: From research to regulation scientific workshop report

Kleinstreuer, Nicole C., Sullivan, Kristie, Allen, David, Edwards, Stephen, Mendrick, Donna L., Embry, Michelle, Matheson, Joanna, Rowlands, J. Craig, Munn, Sharon, Maull, Elizabeth, Casey, Warren

Journal:

Regulatory Toxicology and Pharmacology

Year:

2016

Language:

english

File:

PDF, 850 KB

english, 2016

2

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Kleinstreuer, Nicole C, Yang, Jian, Berg, Ellen L, Knudsen, Thomas B, Richard, Ann M, Martin, Matthew T, Reif, David M, Judson, Richard S, Polokoff, Mark, Dix, David J, Kavlock, Robert J, Houck, Keith

Journal:

Nature Biotechnology

Year:

2014

Language:

english

File:

PDF, 1.72 MB

english, 2014

3

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

Mansouri, Kamel, Kleinstreuer, Nicole, Abdelaziz, Ahmed M., Alberga, Domenico, Alves, Vinicius M., Andersson, Patrik L., Andrade, Carolina H., Bai, Fang, Balabin, Ilya, Ballabio, Davide, Benfenati, Em

Journal:

Environmental Health Perspectives

Year:

2020

Language:

english

File:

PDF, 2.70 MB

english, 2020

4

Multivariate models for prediction of human skin sensitization hazard

Strickland, Judy, Zang, Qingda, Paris, Michael, Lehmann, David M., Allen, David, Choksi, Neepa, Matheson, Joanna, Jacobs, Abigail, Casey, Warren, Kleinstreuer, Nicole

Journal:

Journal of Applied Toxicology

Year:

2016

Language:

english

File:

PDF, 335 KB

english, 2016

5

Identifying Environmental Chemicals as Agonists of the Androgen Receptor by Using a Quantitative High-throughput Screening Platform

Lynch, Caitlin, Sakamuru, Srilatha, Huang, Ruili, Stavreva, Diana A., Varticovski, Lyuba, Hager, Gordon L., Judson, Richard S., Houck, Keith A., Kleinstreuer, Nicole C., Casey, Warren, Paules, Richard

Journal:

Year:

2017

Language:

english

File:

PDF, 1.55 MB

english, 2017

6

Identification and profiling of environmental chemicals that inhibit the TGFβ/SMAD signaling pathway

Wei, Zhengxi, Sakamuru, Srilatha, Zhang, Li, Zhao, Jinghua, Huang, Ruili, Kleinstreuer, Nicole C., Chen, Yanling, Shu, Yan, Knudsen, Thomas B., Xia, Menghang

Journal:

Chemical Research in Toxicology

Year:

2019

File:

PDF, 1.45 MB

2019

7

High-Throughput Screening to Predict Chemical-Assay Interference

Borrel, Alexandre, Huang, Ruili, Sakamuru, Srilatha, Xia, Menghang, Simeonov, Anton, Mansouri, Kamel, Houck, Keith A., Judson, Richard S., Kleinstreuer, Nicole C.

Journal:

Scientific Reports

Year:

2020

File:

PDF, 2.89 MB

2020

8

Exploring Drug Space with ChemMaps.com

Borrel, Alexandre, Kleinstreuer, Nicole, Fourches, Denis

Journal:

Year:

2018

Language:

english

File:

PDF, 304 KB

english, 2018

9

Are we ready for alternative testing?

Beekhuijzen, Manon, Kleinstreuer, Nicole

Journal:

Reproductive Toxicology

Year:

2018

Language:

english

File:

PDF, 87 KB

english, 2018

10

Environmental Impact on Vascular Development Predicted by High-Throughput Screening

Kleinstreuer, Nicole C., Judson, Richard S., Reif, David M., Sipes, Nisha S., Singh, Amar V., Chandler, Kelly J., DeWoskin, Rob, Dix, David J., Kavlock, Robert J., Knudsen, Thomas B.

Journal:

Environmental Health Perspectives

Year:

2011

Language:

english

File:

PDF, 532 KB

english, 2011

11

Correction to Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

Browne, Patience, Judson, Richard S., Casey, Warren, Kleinstreuer, Nicole, Thomas, Russell S.

Journal:

Environmental Science & Technology

Year:

2017

Language:

english

File:

PDF, 146 KB

english, 2017

12

Open-source QSAR models for pKa prediction using multiple machine learning approaches

Mansouri, Kamel, Cariello, Neal F., Korotcov, Alexandru, Tkachenko, Valery, Grulke, Chris M., Sprankle, Catherine S., Allen, David, Casey, Warren M., Kleinstreuer, Nicole C., Williams, Antony J.

Journal:

Journal of Cheminformatics

Year:

2019

Language:

english

File:

PDF, 4.86 MB

english, 2019

13

A Vision of Toxicity Testing in the 21st Century

McKim, Jim, Goldberg, Alan, Kleinstreuer, Nicole, Busquet, Francois, Andersen, Melvin

Journal:

Applied In Vitro Toxicology

Year:

2015

Language:

english

File:

PDF, 136 KB

english, 2015

14

Prediction of skin sensitization potency using machine learning approaches

Zang, Qingda, Paris, Michael, Lehmann, David M., Bell, Shannon, Kleinstreuer, Nicole, Allen, David, Matheson, Joanna, Jacobs, Abigail, Casey, Warren, Strickland, Judy

Journal:

Journal of Applied Toxicology

Year:

2017

Language:

english

File:

PDF, 495 KB

english, 2017

15

Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database

Hoffmann, Sebastian, Kleinstreuer, Nicole, Alépée, Nathalie, Allen, David, Api, Anne Marie, Ashikaga, Takao, Clouet, Elodie, Cluzel, Magalie, Desprez, Bertrand, Gellatly, Nichola, Goebel, Carsten, Ker

Journal:

Critical Reviews in Toxicology

Year:

2018

Language:

english

File:

PDF, 1.62 MB

english, 2018

16

Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

Chandler, Kelly J., Barrier, Marianne, Jeffay, Susan, Nichols, Harriette P., Kleinstreuer, Nicole C., Singh, Amar V., Reif, David M., Sipes, Nisha S., Judson, Richard S., Dix, David J., Kavlock, Rober

Journal:

Year:

2011

Language:

english

File:

PDF, 901 KB

english, 2011

17

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance

Kolanjiyil, Arun V., Kleinstreuer, Clement, Kleinstreuer, Nicole C., Pham, Wellington, Sadikot, Ruxana T.

Journal:

Respiratory Physiology & Neurobiology

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

18

Identification and profiling of environmental chemicals that inhibit the TGFβ/SMAD signaling pathway

Wei, Zhengxi, Sakamuru, Srilatha, Zhang, Li, Zhao, Jinghua, Huang, Ruili, Kleinstreuer, Nicole C., Chen, Yanling, Shu, Yan, Knudsen, Thomas B., Xia, Menghang

Journal:

Chemical Research in Toxicology

Year:

2019

Language:

english

File:

PDF, 1.45 MB

english, 2019

19

An evaluation framework for new approach methodologies (NAMs) for human health safety assessment

Parish, Stanley T., Aschner, Michael, Casey, Warren, Corvaro, Marco, Embry, Michelle R., Fitzpatrick, Suzanne, Kidd, Darren, Kleinstreuer, Nicole C., Lima, Beatriz Silva, Settivari, Raja S., Wolf, Dou

Journal:

Regulatory Toxicology and Pharmacology

Year:

2020

Language:

english

File:

PDF, 4.40 MB

english, 2020

20

The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them

Smith, Martyn T., Guyton, Kathryn Z., Kleinstreuer, Nicole, Borrel, Alexandre, Cardenas, Andres, Chiu, Weihsueh A., Felsher, Dean W., Gibbons, Catherine F., Goodson, William H, Houck, Keith A., Kane,

Journal:

Cancer Epidemiology Biomarkers & Prevention

Year:

2020

File:

PDF, 1.85 MB

2020

21

Non-animal methods to predict skin sensitization (II): an assessment of defined approaches

Kleinstreuer, Nicole C., Hoffmann, Sebastian, Alépée, Nathalie, Allen, David, Ashikaga, Takao, Casey, Warren, Clouet, Elodie, Cluzel, Magalie, Desprez, Bertrand, Gellatly, Nichola, Göbel, Carsten, Ker

Journal:

Critical Reviews in Toxicology

Year:

2018

Language:

english

File:

PDF, 1.49 MB

english, 2018

22

Environmental Impact on Vascular Development Predicted by High-Throughput Screening

Nicole C. Kleinstreuer, Richard S. Judson, David M. Reif, Nisha S. Sipes, Amar V. Singh, Kelly J. Chandler, Rob DeWoskin, David J. Dix, Robert J. Kavlock and Thomas B. Knudsen

Journal:

Environmental Health Perspectives

Year:

2011

Language:

english

File:

PDF, 2.42 MB

english, 2011

23

Tox21BodyMap: a webtool to map chemical effects on the human body

Borrel, Alexandre, Auerbach, Scott S, Houck, Keith A, Kleinstreuer, Nicole C

Journal:

Nucleic Acids Research

Year:

2020

File:

PDF, 1.09 MB

2020

24

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

Thomas B. Knudsen, Keith A. Houck, Nisha S. Sipes, Amar V. Singh, Richard S. Judson, Matthew T. Martin, Arthur Weissman, Nicole C. Kleinstreuer, Holly M. Mortensen, David M. Reif, James R. Rabinowitz,

Journal:

Year:

2011

Language:

english

File:

PDF, 1.68 MB

english, 2011

25

Selecting a minimal set of androgen receptor assays for screening chemicals

Judson, Richard, Houck, Keith, Paul Friedman, Katie, Brown, Jason, Browne, Patience, Johnston, Paul A., Close, David A., Mansouri, Kamel, Kleinstreuer, Nicole

Journal:

Regulatory Toxicology and Pharmacology

Year:

2020

File:

PDF, 2.09 MB

2020

26

Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

El-Masri, Hisham, Kleinstreuer, Nicole, Hines, Ronald N., Adams, Linda, Tal, Tamara, Isaacs, Kristin, Wetmore, Barbara A., Tan, Yu-Mei

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 1.06 MB

english, 2016

27

QSAR models of human data can enrich or replace LLNA testing for human skin sensitization

Alves, Vinicius, capuzzi, Stephen, Muratov, Eugene, Braga, Rodolpho, Thornton, Thomas, Fourches, Denis, Strickland, Judy, Kleinstreuer, Nicole, Andrade, carolina, Tropsha, A

Journal:

Green Chemistry

Year:

2016

Language:

english

File:

PDF, 1.93 MB

english, 2016

28

New Approach Methods for Testing Chemicals for Endocrine Disruption Potential

Judson, Richard S., Paul Friedman, Katie, Houck, Keith, Mansouri, Kamel, Browne, Patience, Kleinstreuer, Nicole C.

Journal:

Current Opinion in Toxicology

Year:

2018

Language:

english

File:

PDF, 829 KB

english, 2018

29

Computational Toxicology

Kleinstreuer, Nicole C., Tong, Weida, Tetko, Igor V.

Journal:

Chemical Research in Toxicology

Year:

2020

Language:

english

File:

PDF, 812 KB

english, 2020

30

Application of Reverse Dosimetry to Compare In Vitro and In Vivo Estrogen Receptor Activity

Chang, Xiaoqing, Kleinstreuer, Nicole, Ceger, Patricia, Hsieh, Jui-Hua, Allen, Dave, Casey, Warren

Journal:

Applied In Vitro Toxicology

Year:

2015

Language:

english

File:

PDF, 462 KB

english, 2015

31

Systems Modeling of Developmental Vascular Toxicity

Saili, Katerine S., Franzosa, Jill A., Baker, Nancy C., Ellis-Hutchings, Robert G., Settivari, Raja S., Carney, Edward W., Spencer, Richard, Zurlinden, Todd J., Kleinstreuer, Nicole C., Li, Shuaizhang

Journal:

Current Opinion in Toxicology

Year:

2019

File:

PDF, 12.72 MB

2019

32

Identification of potential endocrine disrupting chemicals using gene expression biomarkers

Corton, J. Christopher, Kleinstreuer, Nicole C., Judson, Richard S.

Journal:

Toxicology and Applied Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.18 MB

english, 2019

33

Integrated decision strategies for skin sensitization hazard

Strickland, Judy, Zang, Qingda, Kleinstreuer, Nicole, Paris, Michael, Lehmann, David M., Choksi, Neepa, Matheson, Joanna, Jacobs, Abigail, Lowit, Anna, Allen, David, Casey, Warren

Journal:

Journal of Applied Toxicology

Year:

2016

Language:

english

File:

PDF, 485 KB

english, 2016

34

Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds

Alves, Vinicius M., Muratov, Eugene, Fourches, Denis, Strickland, Judy, Kleinstreuer, Nicole, Andrade, Carolina H., Tropsha, Alexander

Journal:

Toxicology and Applied Pharmacology

Year:

2015

Language:

english

File:

PDF, 1019 KB

english, 2015

35

embryonic vascular disruption Adverse outcomes: Linking HIGH Throughput signaling Signatures with Functional Consequences

Ellis-Hutchings, Robert G., Settivari, Raja S., McCoy, Alene T., Kleinstreuer, Nicole, Franzosa, Jill, Knudsen, Thomas B., Carney, Edward W.

Journal:

Reproductive Toxicology

Year:

2017

Language:

english

File:

PDF, 1.58 MB

english, 2017

36

Open-source QSAR models for pKa prediction using multiple machine learning approaches

Mansouri, Kamel, Cariello, Neal F., Korotcov, Alexandru, Tkachenko, Valery, Grulke, Chris M., Sprankle, Catherine S., Allen, David, Casey, Warren M., Kleinstreuer, Nicole C., Williams, Antony J.

Journal:

Journal of Cheminformatics

Year:

2019

File:

PDF, 4.86 MB

2019

37

A Curated Database of Rodent Uterotrophic Bioactivity

Kleinstreuer, Nicole C., Ceger, Patricia C., Allen, David G., Strickland, Judy, Chang, Xiaoqing, Hamm, Jonathan T., Casey, Warren M.

Journal:

Environmental Health Perspectives

Year:

2016

Language:

english

File:

PDF, 492 KB

english, 2016

38

Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential

Wei, Zhengxi, Liu, Xue, Ooka, Masato, Zhang, Li, Song, Min Jae, Huang, Ruili, Kleinstreuer, Nicole C., Simeonov, Anton, Xia, Menghang, Ferrer, Marc

Journal:

Frontiers in Bioengineering and Biotechnology

Year:

2020

File:

PDF, 4.56 MB

2020

39

Disruption of embryonic vascular development in predictive toxicology

Thomas B. Knudsen, Nicole C. Kleinstreuer

Journal:

Birth Defects Research Part C: Embryo Today: Reviews

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

40

A Computational Model Predicting Disruption of Blood Vessel Development

Kleinstreuer, Nicole, Dix, David, Rountree, Michael, Baker, Nancy, Sipes, Nisha, Reif, David, Spencer, Richard, Knudsen, Thomas, Peirce, Shayn M.

Journal:

PLoS Computational Biology

Year:

2013

Language:

english

File:

PDF, 5.03 MB

english, 2013

41

Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity

Tal, Tamara, Kilty, Claire, Smith, Andrew, LaLone, Carlie, Kennedy, Brendán, Tennant, Alan, McCollum, Catherine W., Bondesson, Maria, Knudsen, Thomas, Padilla, Stephanie, Kleinstreuer, Nicole

Journal:

Reproductive Toxicology

Year:

2016

Language:

english

File:

PDF, 869 KB

english, 2016

42

Integrated decision strategies for skin sensitization hazard

Strickland, Judy, Zang, Qingda, Kleinstreuer, Nicole, Paris, Michael, Lehmann, David M., Choksi, Neepa, Matheson, Joanna, Jacobs, Abigail, Lowit, Anna, Allen, David, Casey, Warren

Journal:

Journal of Applied Toxicology

Year:

2018

Language:

english

File:

PDF, 45 KB

english, 2018

43

Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium

Rooney, John P, Chorley, Brian, Kleinstreuer, Nicole, Corton, J Christopher

Journal:

Toxicological Sciences

Year:

2018

Language:

english

File:

PDF, 971 KB

english, 2018

44

In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning

Zang, Qingda, Mansouri, Kamel, Williams, Antony J., Judson, Richard S., Allen, David G., Casey, Warren M., Kleinstreuer, Nicole C.

Journal:

Journal of Chemical Information and Modeling

Year:

2017

Language:

english

File:

PDF, 1.22 MB

english, 2017

45

Predictive Models for Acute Oral Systemic Toxicity: A Workshop to Bridge the Gap from Research to Regulation

Kleinstreuer, Nicole C, Karmaus, Agnes, Mansouri, Kamel, Allen, David G, Fitzpatrick, Jeremy M, Patlewicz, Grace

Journal:

Computational Toxicology

Year:

2018

Language:

english

File:

PDF, 945 KB

english, 2018

46

A C. elegans Screening Platform for the Rapid Assessment of Chemical Disruption of Germline Function

Allard, Patrick, Kleinstreuer, Nicole C., Knudsen, Thomas B., Colaiácovo, Monica P.

Journal:

Environmental Health Perspectives

Year:

2013

Language:

english

File:

PDF, 2.08 MB

english, 2013

47

Development and Validation of a Computational Model for Androgen Receptor Activity

Kleinstreuer, Nicole C., Ceger, Patricia, Watt, Eric D., Martin, Matthew, Houck, Keith, Browne, Patience, Thomas, Russell S., Casey, Warren M., Dix, David J., Allen, David, Sakamuru, Srilatha, Xia, Me

Journal:

Chemical Research in Toxicology

Year:

2017

Language:

english

File:

PDF, 3.44 MB

english, 2017

48

Systems Modeling of Developmental Vascular Toxicity

Saili, Katerine S., Franzosa, Jill A., Baker, Nancy C., Ellis-Hutchings, Robert G., Settivari, Raja S., Carney, Edward W., Spencer, Richard, Zurlinden, Todd J., Kleinstreuer, Nicole C., Li, Shuaizhang

Journal:

Current Opinion in Toxicology

Year:

2019

Language:

english

File:

PDF, 12.72 MB

english, 2019

49

Computational toxicology and in silico modeling of embryogenesis

Thomas B. Knudsen, Nisha S. Sipes, Nicole C. Kleinstreuer, Michael R. Rountree, Nancy C. Baker, Richard M. Spencer, Kelly J. Chandler, Stephanie Padilla, Tamara Tal, E. Sidney Hunter

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 49 KB

english, 2012

50

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

Alves, Vinicius M., Muratov, Eugene, Fourches, Denis, Strickland, Judy, Kleinstreuer, Nicole, Andrade, Carolina H., Tropsha, Alexander

Journal:

Toxicology and Applied Pharmacology

Year:

2015

Language:

english

File:

PDF, 675 KB

english, 2015

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